Evid Based Nurs 3:9 doi:10.1136/ebn.3.1.9
  • Treatment

In newborns, changing parenteral nutrition sets every 48 hours rather than every 24 hours did not increase infusate contamination

 QUESTION: In newborn infants, does changing total parenteral nutrition fluid administration sets (TASs) every 48 hours, rather than every 24 hours, increase the rate of contamination of infusates (amino acid plus dextrose solution [AADS] or lipid emulsion)?


Randomised (allocation not concealed), blinded (unclear), controlled trial.


A neonatal intensive care unit in Edmonton, Alberta, Canada.


166 infants who received total parenteral nutrition during a 12 month period. Infusate samples from 148 infants (89%) (mean gestational age 32.8 wks, mean birth weight 2036 g, mean postnatal age 12.9 d) were included in the analysis.


53 infants were allocated to have their TAS changed every 24 hours. 113 infants were allocated to have their TAS changed every 48 hours. The TAS was changed by the bedside nurse assigned to the infant's care. For both groups, bags containing AADS were changed daily, whereas lipid emulsion bottles were changed with …

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