Dietary fibre intake was not associated with a lower risk of colorectal cancer in women
Question Is dietary fibre intake associated with a decreased risk of colorectal cancer and adenoma in women?
Design
Prospective, population based cohort study of women in the Nurses' Health Study with 16 years of follow up.
Setting
United States.
Participants
88 757 women who were nurses between 30 and 55 years of age in 1976. Exclusion criteria were cancer other than non-melanoma skin cancer, ulcerative colitis, Crohn's disease, familial polyposis syndrome, implausible high or low scores for total energy intake, or missing food frequency questionnaire data.
Assessment of risk factors
Nurses completed mailed questionnaires at baseline and every 2 years thereafter. Food frequency questionnaires included information on 61 foods, beverages, and vitamin and mineral supplements. For analysis, nurses were divided into quintiles based on energy adjusted total fibre intake in 1980, 1984, and 1986, with the lowest intake group given the relative risk (RR) of 1.0. Fibre intake was …
