Evid Based Nurs 2:82 doi:10.1136/ebn.2.3.82
  • Treatment

Review: St John's wort is more effective than placebo for mild to moderate depressive disorders

Responder rates for St John's wort (SJW) v control in depressive disorders†

Weighted event rates
Comparison at a mean follow up of 5.1 weeks SJW Control RBI (95% CI) NNT (CI)
SJW v placebo‡ 56% 25% 140% (70 to 239) 4 (3 to 6)
Weighted event rates
Comparison at a mean follow up of 5.6 weeks SJW Control RBR (CI) NNH
†NS = not significant. Other abbreviations defined in glossary; RBI, RBR, NNT, NNH, and CI calculated from data in article.
‡Heterogeneity existed among trials.
SJW v antidepressants 51% 52% 3% (−12 to 16) NS

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