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Calcium reduced PMS symptoms during the luteal phase of the menstrual cycle

https://doi.org/10.1136/ebn.2.2.43

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    Thys-Jacobs S, Starkey P, Bernstein D, et al, and the Premenstrual Syndrome Study Group.Calcium carbonate and the premenstrual syndrome: effects on premenstrual and menstrual symptoms.Am J Obstet Gynecol1998 Aug;179:444–52OpenUrlCrossRefPubMedWeb of Science

    Question Can calcium supplementation reduce the symptoms that occur during the luteal and menstrual phases of the menstrual cycle in women with premenstrual syndrome (PMS)?

    Design

    Randomised, double blind, placebo controlled trial.

    Setting

    12 outpatient health centres in the US.

    Participants

    497 healthy, premenopausal women aged 18–45 years (mean age 33 y, 80% white) who had regular menstrual cycles, a history of cyclically recurring PMS, PMS symptoms of at least moderate severity confirmed by a validated PMS diary for ≥2 menstrual cycles, and ≥1 of the following: mood swings, depression, tension, anxiety, anger, or crying spells. Exclusion criteria were use of analgesics, digitalis, bile acid resin binders, or levonorgestrel; chronic or excessive use of calcium based antacids or calcium supplements; renal disease or colic; …

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    Footnotes

    • Source of funding: SmithKline Beecham Consumer Healthcare.

    • For correspondence: Dr S Thys-Jacobs, St Luke's-Roosevelt Hospital Center, 425 West 59th Street, Suite 9C, New York, NY 10019, USA. Fax +1 212 523 8102.