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Stable term infants with acidaemia had no major adverse outcomes within 48 hours of birth

https://doi.org/10.1136/ebn.2.1.23

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    King TA, Jackson GL, Josey AS, et al.The effect of profound umbilical artery acidemia in term neonates admitted to a newborn nursery.J Pediatr1998 Apr;132:624–9OpenUrlCrossRefPubMedWeb of Science

    Question Do term or near term infants who are stable and have an umbilical artery pH ≤7.0 (fetal acidaemia) have any adverse outcomes in the first 48 hours of life?

    Design

    Cohort analytic study.

    Setting

    A university hospital in Dallas, Texas, USA.

    Participants

    35 newborn infants with acidaemia who were ≥35 weeks gestation, weighed ≥2100 g, had an Apgar score ≥7 at 5 minutes, and had no serious cardiopulmonary disturbance. 35 infants who did not have acidaemia (controls) were identified and matched for gestational age within 1 week of enrolment. Exclusion criteria were obvious congenital anomalies and in utero infections.

    Assessment of risk factors

    Acidaemia was identified within 4–6 hours of birth using double clamped segments of cord for acid base analysis and was categorised as respiratory (PC02 ≥62.5 mm Hg with a base deficit <12 meq/l), metabolic (PC02 <62.5 mm Hg …

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    Footnotes

    • Source of funding: University of Texas Southwestern Medical Center.

    • For correspondence: Dr A R Laptook, UT-Southwestern Medical Center at Dallas, Department of Pediatrics, 5323 Harry Hines Boulevard, Dallas, TX 75235–9063, USA. Fax +1 214 648 2481.