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Systematic review with meta-analysis
Low-dose aspirin reduces morbidity and mortality in pregnant women at high-risk for preeclampsia
  1. Emmanuel Bujold
  1. Faculty of Medicine, Department of Obstetrics and Gynecology, Université Laval, Centre Mère-Enfant du CHU de Québec, Québec, G1V 4G2, Canada
  1. Correspondence to : Dr Emmanuel Bujold, Faculty of Medicine, Department of Obstetrics and Gynecology, Université Laval, Centre Mère-Enfant du CHU de Québec, Québec, Canada; Emmanuel.bujold{at}crchudequebec.ulaval.ca

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Implications for practice and research

  • Daily low-dose aspirin is recommended from 12 weeks’ gestation and onward to women identified at high-risk for preeclampsia.

  • While women with chronic hypertension or personal history of preeclampsia should receive aspirin during pregnancy, further research leading to first-trimester prediction of preeclampsia in low-risk women should be encouraged.

Context

Preeclampsia affects 2–8% of pregnancies and is a leading cause of maternal deaths around the world. It is associated with poor perinatal outcome, primarily due to increased risk of intrauterine growth restriction (IUGR) and medically indicated preterm delivery. Over the last three to four decades, there has been …

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