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  • Vitamin D concentration in newborn cord blood is correlated with maternal intake of supplemental vitamin D, and lower levels are associated with increased risk of the infant developing eczema

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Child health
Quantitative – other
Vitamin D concentration in newborn cord blood is correlated with maternal intake of supplemental vitamin D, and lower levels are associated with increased risk of the infant developing eczema
  1. Edward M Zoratti1,
  2. Ganesa Wegienka2
  1. 1 Depatment of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA
  2. 2 Depatment of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan, USA
  1. Correspondence to : Edward M Zoratti
    Depatment of Internal Medicine, Henry Ford Hospital, 4B One Ford Place, Detroit, MI 48202, USA; ezoratt1{at}hfhs.org

https://doi.org/10.1136/eb-2012-101200

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    Commentary on: Jones AP, Palmer D, Zhang G, et al. Cord blood 25-hydroxyvitamin D3 and allergic disease during infancy. Pediatrics 2012;130:e1128–35.OpenUrlAbstract/FREE Full Text

    Implications for practice and research

    • Conflicting evidence regarding the role of vitamin D in allergic disease highlights the need for well-designed clinical trials.

    • This study and others suggest that early life vitamin D insufficiency may increase eczema risk.

    • Supplementation during pregnancy may increase cord blood vitamin D and subsequent early life exposure.

    Context

    The human fetus is dependent on maternal vitamin D status during gestation. Vitamin D deficiency rates in pregnant women have been reported as being more than 70% in some clinical practices.1 Our understanding of prenatal vitamin D's role in modulating immune function and the risk of developing allergic disorders is still in its infancy. Jones and colleagues recently examined whether vitamin D3 levels in cord blood were associated …

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    Footnotes

    • Competing interests Both EMZ and GW have received research funds from the US NIH to investigate the effects of Vitamin D on allergic disease.