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Implications for practice and research
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Second trimester exposure to antidepressants was associated with preterm birth.
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Third trimester exposure was associated with infant convulsions.
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The absolute risk for both outcomes is extremely low and most infants will not have these complications.
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Decisions about whether to use antidepressants during pregnancy should include the severity of the mother's psychiatric illness.
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Large studies that include severity of the mother's illness need to be conducted.
Context
Approximately 10–20% of women will meet the criteria for major depressive disorder (MDD) during their lifetime, including during pregnancy.1 Rates of antidepressant exposure …
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