Use of antidepressants in the second trimester is associated with reduced pregnancy duration, and third trimester antidepressant use with infant convulsions
- Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
- Correspondence to
: Dr Jennifer L Payne
Department of Psychiatry, Johns Hopkins School of Medicine, 550 N. Broadway, Suite 305, Baltimore, MD 21205, USA;
Implications for practice and research
Second trimester exposure to antidepressants was associated with preterm birth.
Third trimester exposure was associated with infant convulsions.
The absolute risk for both outcomes is extremely low and most infants will not have these complications.
Decisions about whether to use antidepressants during pregnancy should include the severity of the mother's psychiatric illness.
Large studies that include severity of the mother's illness need to be conducted.
Approximately 10–20% of women will meet the criteria for major depressive disorder (MDD) during their lifetime, including during pregnancy.1 Rates of antidepressant exposure …