Evid Based Nurs 16:74-75 doi:10.1136/eb-2012-101002
  • Midwifery
  • Cohort study

Use of antidepressants in the second trimester is associated with reduced pregnancy duration, and third trimester antidepressant use with infant convulsions

  1. Jennifer L Payne
  1. Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
  1. Correspondence to : Dr Jennifer L Payne
    Department of Psychiatry, Johns Hopkins School of Medicine, 550 N. Broadway, Suite 305, Baltimore, MD 21205, USA; jpayne5{at}

Commentary on:

Implications for practice and research

  • Second trimester exposure to antidepressants was associated with preterm birth.

  • Third trimester exposure was associated with infant convulsions.

  • The absolute risk for both outcomes is extremely low and most infants will not have these complications.

  • Decisions about whether to use antidepressants during pregnancy should include the severity of the mother's psychiatric illness.

  • Large studies that include severity of the mother's illness need to be conducted.


Approximately 10–20% of women will meet the criteria for major depressive disorder (MDD) during their lifetime, including during pregnancy.1 Rates of antidepressant exposure …

Free Sample

This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of EBN.
View free sample issue >>

EBN Journal Chat

The EBN Journal Chat offers readers the opportunity to participate in discussion about research articles and commentaries from Evidence Based Nursing (EBN).

How to participate >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

Navigate This Article