Evid Based Nurs 15:108-109 doi:10.1136/ebnurs-2012-100688
  • Adult nursing
  • Systematic review and meta-analysis

Systematic review and meta-analysis of the correlates of cancer-related fatigue

  1. Margaret I Fitch
  1. Oncology Nursing and Patient & Family Support Program, Sunnybrook Odette Cancer Centre, Toronto, Canada
  1. Correspondence to Margaret I Fitch
    Oncology Nursing and Patient & Family Support Program, Sunnybrook Odette Cancer Centre, 2075 Bayview Avenue, Room T2-234, Toronto, ON M4N 3M5, Canada; marg.fitch{at}

Commentary on:

Implications for practice and research

  • Assessment of cancer-related fatigue must take into account both the physical symptoms and psychological distress.

  • Interventions for cancer-related fatigue must emphasise the importance of psychological distress associated with this problematic side effect.

  • Priority should be given to nausea/vomiting when managing cancer-related fatigue.

  • Future research ought to focus on symptom clusters.


Fatigue is one of the most common problems experienced by patients with cancer, regardless of diagnostic site or treatment modality. Differing from fatigue experienced by the general population, fatigue in cancer is not relieved with rest. It is pervasive and can have a profound effect on quality of life. Generally, patients with cancer develop their own approaches to deal with this challenge, but may not always …

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