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Previous studies—the Diabetes Control and Complications Trial1 in type 1 diabetes and the United Kingdom Prospective Diabetes Study2 in type 2 diabetes—have clearly demonstrated the benefits of intensive glucose control for the prevention of the microvascular complications of diabetes (neuropathy, nephropathy and retinopathy). In addition, long-term follow-up of the younger subjects with type 1 diabetes who were enrolled in the Diabetes Control and Complications Trial demonstrated that those in the intensive arm had a reduced risk of developing cardiovascular disease (CVD), long after the initial phase of the study.3 However, the effects …
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