rss
Evid Based Nurs 13:19-20 doi:10.1136/ebn1021
  • Therapeutics
  • Systematic review

Low-quality evidence that atovaquone-proguanil and doxycycline are better tolerated prophylactic antimalarial regimens in travellers than mefloquine

  1. Michael Hawkes
  1. Michael Hawkes
    Institute of Medical Sciences, University of Toronto, 10-401, 101 College Street, Toronto, Ontario, Canada M5G 1L7; Michael.hawkes{at}utoronto.ca

Commentary on:

An estimated 10,000–30,000 cases of malaria occur annually in travellers, of which 150 cases are fatal. Prevention strategies include avoidance of the night- biting anopheles mosquito vector, patient education to seek medical attention promptly in case of fever, presumptive selftreatment and drugs to prevent malaria, which was the primary focus of the systematic review by Jacquerioz and Croft. Evolving patterns of drug resistance, exemplified most recently by reports of artemisin resistance in Southeast Asia,1 require periodic review of chemoprophylaxis recommendations for travellers.

The scope of this review is the prevention of Plasmodium falciparum, which is the malaria species that causes the overwhelming majority of severe disease and death, and which in many areas of the world is frequently resistant to the classical antimalarial agent chloroquine. This review further focuses on the non-immune traveller without prior malaria exposure, who has a …

Free Sample

This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of EBN.
View free sample issue >>

EBN Journal Chat

The EBN Journal Chat offers readers the opportunity to participate in discussion about research articles and commentaries from Evidence Based Nursing (EBN).

How to participate >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

Navigate This Article