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Intravascular catheter dressings with chlorhexidine-impregnated sponges reduced infections in the ICU

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Questions

Do intravascular catheter dressings with chlorhexidine gluconate–impregnated sponges (CHGISs) reduce catheter-related infections (CRIs) compared with standard dressings in intensive care unit (ICU) patients? Are dressing changes every 7 days non-inferior to changes every 3 days?

Methods

Design:

2 × 2 factorial randomised controlled trial. Clinicaltrials.gov NCT00417235.

Allocation:

{concealed}.*

Blinding:

blinded (microbiologists, outcome assessors, {data analysts, and safety committee}*).

Follow-up period:

48 hours after ICU discharge.

Setting:

7 ICUs in 3 university and 2 general hospitals in France.

Patients:

1653 patients >18 years of age (median age 62 y, 64% men, based on 1636 patients) requiring catheters for ⩾48 hours. Exclusion criteria were allergy to chlorhexidine or transparent dressings.

Interventions:

CHGIS dressings, 3-day change (n = 412); CHGIS dressings, 7-day change (n = 413); standard dressings, 3-day change (n = 416); or standard dressings, 7-day change (n = 412). In all …

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