Article Text
Statistics from Altmetric.com
Question
Do inhaled corticosteroids (ICSs) reduce wheezing/asthma exacerbations (WAEs) in infants and preschool children with a previous diagnosis of wheezing or asthma?
Review scope
Included studies were randomised controlled trials (RCTs) of ⩾4 weeks of treatment that compared an ICS with placebo in infants and children ⩽5 years of age with a diagnosis of wheezing or asthma for ⩾6 months before study entry. Outcomes were WAEs (worsening symptoms that required systemic corticosteroids), withdrawal from study due to WAEs, change in symptom score, change in salbutamol(albuterol) use, and change in pulmonary function (FEV1 and peak expiratory flow [PEF]).
Review methods
Medline, EMBASE/Excerpta Medica, and Cochrane Central Register of Controlled Trials (all to Mar or second quarter 2008) were searched for RCTs. 29 RCTs {n = 3992, mean age 40 mo}* …
Footnotes
-
Source of funding no external funding.