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Review: pneumococcal vaccination does not prevent pneumonia, bacteraemia, bronchitis, or mortalityCommentary

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QUESTION

Is pneumococcal vaccination effective for various clinical outcomes in adults?

REVIEW SCOPE

Included studies compared pneumococcal polysaccharide vaccine with placebo, other vaccines, or no intervention (control). Studies of children; evaluating antibody responses only or pneumococcal polysaccharide vaccines as a booster after receipt of conjugate pneumococcal vaccine; or animal, laboratory, and observational intervention studies were excluded. Outcomes were definitive pneumococcal pneumonia, presumptive pneumococcal pneumonia, all-cause pneumonia, bacteraemia, bronchitis, all-cause mortality, pneumonia mortality, and mortality from pneumococcal infection.

REVIEW METHODS

Medline (1966 to May 2007), EMBASE/Excerpta Medica (1974 to May 2007), Cochrane Central Register of Controlled Trials, Latin American and Caribbean Health Sciences Literature, Indian Medlars Centre, African Index Medicus, …

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