Review: pneumococcal vaccination does not prevent pneumonia, bacteraemia, bronchitis, or mortality
Is pneumococcal vaccination effective for various clinical outcomes in adults?
Included studies compared pneumococcal polysaccharide vaccine with placebo, other vaccines, or no intervention (control). Studies of children; evaluating antibody responses only or pneumococcal polysaccharide vaccines as a booster after receipt of conjugate pneumococcal vaccine; or animal, laboratory, and observational intervention studies were excluded. Outcomes were definitive pneumococcal pneumonia, presumptive pneumococcal pneumonia, all-cause pneumonia, bacteraemia, bronchitis, all-cause mortality, pneumonia mortality, and mortality from pneumococcal infection.
Medline (1966 to May 2007), EMBASE/Excerpta Medica (1974 to May 2007), Cochrane Central Register of Controlled Trials, Latin American and Caribbean Health Sciences Literature, Indian Medlars Centre, African Index Medicus, …