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Oral prednisolone did not improve outcomes in preschool children with an attack of virus-induced wheezingCommentary

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QUESTION

Does a short course of oral prednisolone improve outcomes in preschool children with an attack of wheezing associated with upper respiratory viral infection?

METHODS

Design:

randomised placebo-controlled trial. ISRCTN58363576.

Allocation:

concealed.

Blinding:

blinded (patients, parents, healthcare providers, and outcome assessors).

Follow-up period:

1 month.

Setting:

3 hospitals in the UK.

Patients:

700 children 10–60 months of age (mean age 26 mo, 64% boys) who presented to hospital with an attack of wheezing associated with a clinically diagnosed upper respiratory viral infection. Exclusion criteria included shock, bacterial sepsis, heart or lung disease, immunodeficiency or immunosuppressive therapy, and varicella infection or recent exposure.

Intervention:

oral prednisolone (10 mg/d if ⩽24 mo of age or 20 mg/d if …

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