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Evid Based Nurs 12:56 doi:10.1136/ebn.12.2.56
  • Treatment

Ginkgo biloba did not prevent dementia or Alzheimer disease in elderly people

S T DeKosky

Dr S T DeKosky, University of Virginia School of Medicine, Charlottesville, VA, USA; dekosky@virginia.edu

QUESTION

Does Ginkgo biloba reduce incident dementia and Alzheimer disease in elderly people with normal cognition or mild cognitive impairment?

METHODS

Design:

randomised placebo controlled trial (Ginkgo Evaluation of Memory [GEM] study). ClinicalTrials.gov NCT00010803.

Allocation:

unclear allocation concealment.*

Blinding:

blinded (patients, clinicians, and outcome assessors).*

Follow-up period:

median 6.1 years.

Setting:

5 academic medical centres in the USA.

Participants:

3069 participants >75 years of age (mean age 79 y, 54% men) who had normal cognition or mild cognitive impairment (impaired at ⩽10th percentile of Cardiovascular Health Study normative data on 2 of 10 neuropsychological tests and Clinical Dementia Rating …

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