rss
Evid Based Nurs 12:48 doi:10.1136/ebn.12.2.48
  • Treatment

Vitamin E or vitamin C supplements did not differ from placebo for major cardiovascular events and mortality

H D Sesso

Dr H D Sesso, Brigham and Women’s Hospital, Boston, MA, USA; hsesso@hsph.harvard.edu

QUESTION

In men at lower risk of cardiovascular disease (CVD), do vitamin E and vitamin C supplements reduce major CVD events?

METHODS

Design:

randomised placebo controlled trial (Physicians’ Health Study II). ClinicalTrials.gov NCT00270647.

Allocation:

unclear allocation concealment.

Blinding:

blinded (patients, clinicians, and outcome assessors)

Follow-up period:

⩽10 years (mean 8 y).

Setting:

USA.

Patients:

14 641 male physicians ⩾50 years of age (mean age 64 y). Men with a history of myocardial infarction (MI), stroke, or cancer were included. Exclusion criteria were history of cirrhosis, active liver disease, anticoagulant use, or serious illness. 5.1% of men had prevalent CVD.

Intervention:

after stratification for age, previous cancer or …

No Related Web Pages

Free Sample

This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of EBN.
View free sample issue >>

EBN Journal Chat

The EBN Journal Chat offers readers the opportunity to participate in discussion about research articles and commentaries from Evidence Based Nursing (EBN).

How to participate >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

Navigate This Article