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Excess mortality after HIV seroconversion has greatly decreased in the past 10 years

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K Porter

Dr K Porter, MRC Clinical Trials Unit, London, UK; kp@ctu.mrc.ac.uk

QUESTIONS

What is the risk of death in HIV-infected people compared with the general population? Has this risk changed since the introduction of highly active antiretroviral therapy (HAART)?

METHODS

Design:

inception cohort followed up for a median 6.3 years.

Setting:

10 European countries, Australia, and Canada.

Patients:

16 534 patients ⩾15 years of age at HIV seroconversion (median age 29 y, 78% men) who had well-estimated dates of seroconversion (within 18 mo) and exposure to HIV through injection drug use (18% of patients), sex between men (57%), or heterosexual sex (24%).

Prognostic factors:

calendar period of follow-up (before 1996, 1996–7, 1998–9, 2000–1, 2002–3, and 2004–6), sex, age at seroconversion, and HIV exposure category.

Outcomes:

mortality, excess …

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