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Benefits of early intensive glucose control in preventing diabetes-related complications were sustained for up to 10 yearsCommentary

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R R Holman

Dr R R Holman, Churchill Hospital, Oxford, UK; rury.holman@dtu.ox.ac.uk

QUESTION

In patients with type 2 diabetes, do the benefits of early intensive glucose control in preventing diabetes-related complications continue after the intervention is stopped?

METHODS

Design:

randomised controlled trial (UK Prospective Diabetes Study [UKPDS]).

Allocation:

{concealed}.*

Blinding:

blinded (outcome adjudication committee).

Follow-up period:

median 9 years after the end of the trial, 17 years total.

Setting:

23 centres in the UK.

Patients:

4209 patients 25–65 years of age {mean age 53 y, 60% men}* who had newly diagnosed type 2 diabetes and fasting plasma glucose concentrations >6.0 mmol/l (108 mg/dl) and <15.0 mmol/l (270 mg/dl) after 3 months of dietary therapy. Exclusion criteria included ketonuria, elevated serum creatinine, recent myocardial infarction, angina, …

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