rss
Evid Based Nurs 12:12-13 doi:10.1136/ebn.12.1.12
  • Treatment

Intensive glucose control did not prevent important complications in type 2 diabetes

A Patel

Dr A Patel, University of Sydney, Sydney, New South Wales, Australia; apatel@george.org.au

QUESTION

In type 2 diabetes, does intensive glucose control prevent adverse outcomes more than standard glucose control?

METHODS

Design:

randomised controlled trial (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation [ADVANCE]).

Allocation:

concealed.

Blinding:

blinded (outcome adjudication committee).

Follow-up period:

median 5 years.

Setting:

215 centres in 20 countries worldwide.

Patients:

11 140 patients ⩾55 years of age (mean age 66 y, 58% men) who had type 2 diabetes and a history of, or risk factors for, vascular disease. Patients requiring insulin were excluded.

Intervention:

intensive glucose control with gliclazide, modified-release, 30–120 mg/day, and other non-sulfonylurea drugs as needed to achieve a target glycated haemoglobin (HbA1c) concentration ⩽6.5% (n = 5571) or standard glucose control with drugs other than gliclazide (n = 5569).

Outcomes:

composite of major macrovascular events (non-fatal myocardial infarction or stroke, or death from cardiovascular causes) and composite of major microvascular events (new or worsening nephropathy or retinopathy). Secondary outcomes included new-onset microalbuminuria and severe hypoglycaemia.

Patient follow-up:

95% (intention-to-treat analysis). …

No Related Web Pages

Free Sample

This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of EBN.
View free sample issue >>

EBN Journal Chat

The EBN Journal Chat offers readers the opportunity to participate in discussion about research articles and commentaries from Evidence Based Nursing (EBN).

How to participate >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

Navigate This Article