Enalapril and captopril increased mortality compared with ramipril in elderly patients with heart failure
L Pilote
Dr L Pilote, McGill University Health Centre, Montreal, Quebec, Canada; louise.pilote@mcgill.ca
QUESTION
Does type of angiotensin-converting enzyme (ACE) inhibitor prescribed affect mortality in elderly patients with heart failure?
METHODS
Design:
retrospective cohort study using government administrative databases, with mean follow-up of 2.1 years.
Setting:
Ontario, Quebec, and British Columbia, Canada.
Patients:
43 316 patients 65–105 years of age (median age 78 y, 52% women) who were discharged from hospital over a 4.25–year period with a primary diagnosis of heart failure, had not been admitted to hospital for this indication in the previous 3 years, and filled a prescription for an ACE inhibitor within 30 days of discharge.
Risk factor:
type …
