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Evid Based Nurs 11:123 doi:10.1136/ebn.11.4.123
  • Causation

Enalapril and captopril increased mortality compared with ramipril in elderly patients with heart failure

L Pilote

Dr L Pilote, McGill University Health Centre, Montreal, Quebec, Canada; louise.pilote@mcgill.ca

QUESTION

Does type of angiotensin-converting enzyme (ACE) inhibitor prescribed affect mortality in elderly patients with heart failure?

METHODS

Design:

retrospective cohort study using government administrative databases, with mean follow-up of 2.1 years.

Setting:

Ontario, Quebec, and British Columbia, Canada.

Patients:

43 316 patients 65–105 years of age (median age 78 y, 52% women) who were discharged from hospital over a 4.25–year period with a primary diagnosis of heart failure, had not been admitted to hospital for this indication in the previous 3 years, and filled a prescription for an ACE inhibitor within 30 days of discharge.

Risk factor:

type …

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