Article Text

PDF
Review: evidence for use of systemic antibiotics and topical antiseptics for venous leg ulcers is insufficientCommentary

Statistics from Altmetric.com

S O’Meara

Ms S O’Meara, University of York, York, UK; smo4@york.ac.uk

QUESTION

Are systemic antibiotics and topical antibiotics and antiseptics effective for treatment of venous leg ulcers?

REVIEW SCOPE

Studies selected compared systemic antibiotics or topical antibiotics or antiseptics with placebo, no treatment, usual care, another antibiotic or antiseptic, or another treatment in patients with venous leg ulcers. Studies involving topical silver-based preparations or honey were excluded. Outcomes were objective measures of wound healing (time to healing, proportion of ulcers completely healed, change in ulcer size, or healing rate).

REVIEW METHODS

Cochrane Wounds Group Specialised Register, Medline, CINAHL, and EMBASE/Excerpta Medica (to Oct 2007); Cochrane Central Register of Controlled Trials (Issue 4, 2007); and reference lists were searched for randomised controlled trials (RCTs). 22 RCTs met the selection criteria; treatments assessed were systemic antibiotics (5 RCTs, n = 232), cadexomer iodine (10 RCTs, n = 645), povidone iodine (2 RCTs, n = 300), peroxides (3 RCTs, n = 83), and miscellaneous topical preparations (2 RCTs, n = 283). Median duration of follow-up was 6 …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.