rss
Evid Based Nurs 11:88 doi:10.1136/ebn.11.3.88
  • Treatment

Review: evidence for use of systemic antibiotics and topical antiseptics for venous leg ulcers is insufficient

S O’Meara

Ms S O’Meara, University of York, York, UK; smo4@york.ac.uk

QUESTION

Are systemic antibiotics and topical antibiotics and antiseptics effective for treatment of venous leg ulcers?

REVIEW SCOPE

Studies selected compared systemic antibiotics or topical antibiotics or antiseptics with placebo, no treatment, usual care, another antibiotic or antiseptic, or another treatment in patients with venous leg ulcers. Studies involving topical silver-based preparations or honey were excluded. Outcomes were objective measures of wound healing (time to healing, proportion of ulcers completely healed, change in ulcer size, or healing rate).

REVIEW METHODS

Cochrane Wounds Group Specialised Register, Medline, CINAHL, and EMBASE/Excerpta Medica (to Oct 2007); Cochrane Central Register of Controlled Trials (Issue 4, 2007); and reference lists were searched for randomised controlled trials (RCTs). 22 RCTs met the selection criteria; treatments assessed were systemic antibiotics (5 RCTs, n = 232), cadexomer iodine (10 RCTs, n = 645), povidone iodine (2 RCTs, n = 300), peroxides (3 RCTs, n = 83), and miscellaneous topical preparations (2 RCTs, n = 283). Median duration of follow-up was 6 …

Free Sample

This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of EBN.
View free sample issue >>

EBN Journal Chat

The EBN Journal Chat offers readers the opportunity to participate in discussion about research articles and commentaries from Evidence Based Nursing (EBN).

How to participate >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

Navigate This Article