rss
Evid Based Nurs 11:53 doi:10.1136/ebn.11.2.53
  • Treatment

Both low-dose and micro-dose 17β-oestradiol are effective for postmenopausal hot flushes

G A Bachmann

Dr G A Bachmann, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA; gloria.bachmann@umdnj.edu

QUESTION

Does micro-dose 17β-oestradiol reduce the frequency and severity of hot flushes in symptomatic postmenopausal women?

METHODS

Design:

randomised, placebo-controlled trial.

Allocation:

concealed.

Blinding:

blinded (patients, clinicians, and data collectors).

Follow-up period:

12 weeks.

Setting:

48 centres in the US.

Patients:

425 healthy postmenopausal women ⩾40 years of age (mean age 53 y) who had an average of ⩾7 moderate or severe hot flushes per day for ⩾1 week during screening. Women taking hormone therapy or other drugs that might affect vasomotor symptoms underwent a wash-out period. Exclusion criteria included abnormal Pap test result, abnormal vaginal bleeding, and history of thrombophlebitis or thromboembolic disorder.

Intervention:

transdermal …

No Related Web Pages

Free Sample

This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of EBN.
View free sample issue >>

EBN Journal Chat

The EBN Journal Chat offers readers the opportunity to participate in discussion about research articles and commentaries from Evidence Based Nursing (EBN).

How to participate >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

Navigate This Article