Evid Based Nurs 11:53 doi:10.1136/ebn.11.2.53
  • Treatment

Both low-dose and micro-dose 17β-oestradiol are effective for postmenopausal hot flushes

G A Bachmann

Dr G A Bachmann, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA;


Does micro-dose 17β-oestradiol reduce the frequency and severity of hot flushes in symptomatic postmenopausal women?



randomised, placebo-controlled trial.




blinded (patients, clinicians, and data collectors).

Follow-up period:

12 weeks.


48 centres in the US.


425 healthy postmenopausal women ⩾40 years of age (mean age 53 y) who had an average of ⩾7 moderate or severe hot flushes per day for ⩾1 week during screening. Women taking hormone therapy or other drugs that might affect vasomotor symptoms underwent a wash-out period. Exclusion criteria included abnormal Pap test result, abnormal vaginal bleeding, and history of thrombophlebitis or thromboembolic disorder.


transdermal …

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