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Both low-dose and micro-dose 17β-oestradiol are effective for postmenopausal hot flushes

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G A Bachmann

Dr G A Bachmann, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA; gloria.bachmann@umdnj.edu

QUESTION

Does micro-dose 17β-oestradiol reduce the frequency and severity of hot flushes in symptomatic postmenopausal women?

METHODS

Design:

randomised, placebo-controlled trial.

Allocation:

concealed.

Blinding:

blinded (patients, clinicians, and data collectors).

Follow-up period:

12 weeks.

Setting:

48 centres in the US.

Patients:

425 healthy postmenopausal women ⩾40 years of age (mean age 53 y) who had an average of ⩾7 moderate or severe hot flushes per day for ⩾1 week during screening. Women taking hormone therapy or other drugs that might affect vasomotor symptoms underwent a wash-out period. Exclusion criteria included abnormal Pap test result, abnormal vaginal bleeding, and history of thrombophlebitis or thromboembolic disorder.

Intervention:

transdermal …

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