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Primary prevention with pravastatin for 5 years continued to prevent coronary events in the next 10 yearsCommentary

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I Ford

Dr I Ford, University of Glasgow, Glasgow, UK; ian@stats.gla.ac.uk

QUESTION

In middle-aged men with hypercholesterolaemia and no history of myocardial infarction (MI), does 5 years of treatment with pravastatin have long-term benefits for prevention of coronary heart disease (CHD)?

METHODS

Design:

post-trial follow-up of a randomised, placebo-controlled trial (West of Scotland Coronary Prevention Study [WOSCOPS]).

Allocation:

unclear allocation concealment.

Blinding:

blinded during the trial period {clinicians, patients, data collectors, and outcome adjudication committees}.*

Follow-up period:

original trial follow-up was 5 years; this study followed up surviving patients (96%) for 10 more years.

Setting:

{coronary screening clinics in the UK}.*

Patients:

6595 men {45–64 years of age}* (mean age 55 y) with no history of MI and low-density lipoprotein cholesterol concentrations ⩾155 mg/dl (4.01 mmol/l) on 2 occasions.

Intervention:

pravastatin, 40 mg …

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