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Evid Based Nurs 11:11 doi:10.1136/ebn.11.1.11
  • Treatment

Review: vaccines against human papillomavirus prevent cervical cancer precursors in young women

L Rambout

Correspondence to: Ms L Rambout, Ottawa Hospital, Ottawa, Ontario, Canada; lrambout@ottawahospital.on.ca

QUESTION

Do vaccines against human papillomavirus (HPV) prevent cervical cancer precursors in young women?

METHODS

Data sources:

Medline and EMBASE/Excerpta Medica (to May 2007); Medline in process (to June 2007); Cochrane Library and Cochrane Central Register of Controlled Trials (Issue 1, 2007); conference proceedings (2004–7); clinical trial registers; Google Scholar; public health announcements; reference lists; and vaccine manufacturers.

Study selection and assessment:

randomised controlled trials (RCTs) that compared a vaccine against ⩾1 oncogenic type of HPV with placebo or no HPV vaccine for prophylaxis of oncogenic HPV-related infection and disease in women. 9 reports of 6 RCTs (n = 40 323; mean age 20 y, range 15–26 y) met the selection criteria. 1 RCT (n = 2392) evaluated a monovalent HPV 16 vaccine, 2 RCTs …

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