Evid Based Nurs 10:115 doi:10.1136/ebn.10.4.115
  • Treatment

Decontamination of the nasopharynx and oropharynx with chlorhexidine reduced nosocomial infections in cardiac surgery

 Q Does perioperative decontamination of the nasopharynx and oropharynx with chlorhexidine gluconate reduce nosocomial infections after cardiac surgery?



randomised, placebo-controlled trial.




blinded (patients, healthcare providers, data collectors, {outcome assessors, data analysts, safety and monitoring committee, and manuscript writers}*).

GraphicFollow-up period:

up to 30 days.


a community hospital in the Netherlands.


991 patients >18 years of age requiring cardiothoracic surgery. Exclusion criteria included emergency procedures; preoperative infection or use of antimicrobials; hypersensitivity to chlorhexidine; use of an alternative prophylactic regimen; and admission <1 day before surgery.


0.12% chlorhexidine gluconate used as an oral rinse and as a gel for …

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