Article Text

Decontamination of the nasopharynx and oropharynx with chlorhexidine reduced nosocomial infections in cardiac surgery

Statistics from

 Q Does perioperative decontamination of the nasopharynx and oropharynx with chlorhexidine gluconate reduce nosocomial infections after cardiac surgery?


Embedded ImageDesign:

randomised, placebo-controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (patients, healthcare providers, data collectors, {outcome assessors, data analysts, safety and monitoring committee, and manuscript writers}*).

Embedded ImageFollow-up period:

up to 30 days.

Embedded ImageSetting:

a community hospital in the Netherlands.

Embedded ImagePatients:

991 patients >18 years of age requiring cardiothoracic surgery. Exclusion criteria included emergency procedures; preoperative infection or use of antimicrobials; hypersensitivity to chlorhexidine; use of an alternative prophylactic regimen; and admission <1 day before surgery.

Embedded ImageIntervention:

0.12% chlorhexidine gluconate used as an oral rinse and as a gel for …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.