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Decontamination of the nasopharynx and oropharynx with chlorhexidine reduced nosocomial infections in cardiac surgery

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 Q Does perioperative decontamination of the nasopharynx and oropharynx with chlorhexidine gluconate reduce nosocomial infections after cardiac surgery?

METHODS

Embedded ImageDesign:

randomised, placebo-controlled trial.

Embedded ImageAllocation:

concealed.

Embedded ImageBlinding:

blinded (patients, healthcare providers, data collectors, {outcome assessors, data analysts, safety and monitoring committee, and manuscript writers}*).

Embedded ImageFollow-up period:

up to 30 days.

Embedded ImageSetting:

a community hospital in the Netherlands.

Embedded ImagePatients:

991 patients >18 years of age requiring cardiothoracic surgery. Exclusion criteria included emergency procedures; preoperative infection or use of antimicrobials; hypersensitivity to chlorhexidine; use of an alternative prophylactic regimen; and admission <1 day before surgery.

Embedded ImageIntervention:

0.12% chlorhexidine gluconate used as an oral rinse and as a gel for …

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