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4 layer bandages were better than 1 layer bandages, and pentoxifylline may be better than placebo for venous leg ulcers

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 Q In patients with venous leg ulcers, which drug, bandage, and dressing options are most effective for healing?

METHODS

Embedded ImageDesign:

2×2×2 factorial randomised controlled trial.

Embedded ImageAllocation:

concealed.

Embedded ImageBlinding:

partially blinded (patients and healthcare providers were blinded to the drug intervention only).

Embedded ImageFollow up period:

24 weeks.

Embedded ImageSetting:

2 centres in Scotland, UK.

Embedded ImagePatients:

245 patients >18 years of age (mean age 70 y, 67% women) with clinical signs of venous disease and a venous leg ulcer ⩾1 cm in length and ⩾8 weeks in duration. Exclusion criteria included important arterial disease, diabetes, and infected or gangrenous ulcers.

Embedded ImageInterventions:

pentoxifylline, sustained release 400 mg 3 times daily, (n = 121) or placebo (n = 124); 4 layer bandage (n = 117) or adhesive 1 layer bandage (n = 128); and …

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