Review: timing or administration route of nutritional support does not affect death or disability in head injury
Q In patients with head injury, does timing or route of nutritional support affect morbidity and mortality?
Cochrane Injuries Group specialised register, Cochrane Central Register of Controlled Trials, Medline, EMBASE/Excerpta Medica, Web of Science, CAB Abstracts, CINAHL, National Research Register, ZETOC, and reference lists of identified studies and reviews.
Study selection and assessment:
randomised controlled trials (RCTs) evaluating timing (early v delayed) or administration routes (parenteral v enteral or gastric v jejunal enteral) of nutritional support in patients with acute traumatic brain injury of any severity. 11 RCTs (n = 534) met the inclusion criteria. 7 RCTs evaluated timing, and 7 RCTs evaluated administration route. Quality …