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Review: over-the-counter medications are effective for gastro-oesophageal reflux disease

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 Q Are over-the-counter medications effective for gastro-oesophageal reflux disease (GORD)?

METHODS

Embedded ImageData sources:

Medline (to 2005), reference lists, abstracts of scientific meetings, and drug manufacturers.

Embedded ImageStudy selection and assessment:

English language randomised controlled trials (RCTs) that compared an antacid, alginate-antacid combination, or histamine-2 receptor antagonist (H2RA) at over-the-counter doses with placebo for treatment of GORD in adults and reported outcomes of interest (see below). 14 RCTs involving 18 comparisons (n = 7021) met the selection criteria. Quality of individual trials was assessed using the Jadad score.

Embedded ImageOutcomes:

adequate relief of GORD symptoms, …

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