Evid Based Nurs 10:74 doi:10.1136/ebn.10.3.74
  • Treatment

Delivery of a β2 agonist by metered dose inhaler with a bottle spacer was equivalent to delivery by conventional spacer in young children with acute lower airway obstruction

 Q In young children with acute lower airway obstruction, is response to bronchodilator treatment given using a metered dose inhaler (MDI) with a bottle spacer equivalent to that given using a conventional spacer?



randomised controlled equivalence trial.




blinded ({healthcare providers, data collectors},* and clinical outcome assessors).

GraphicFollow up period:

after completion of 3 bronchodilator treatments.


a children’s hospital in Cape Town, South Africa.


400 children aged 2 months to 5 years (median age 12 mo, 39% boys) who presented with clinical signs of acute lower airway obstruction (expiratory wheeze on auscultation or hyperinflation of the chest) and had cough or difficulty breathing within the previous 5 days. Exclusion criteria were bronchodilator use in the previous 4 hours, underlying cardiac or chronic pulmonary disease (other than asthma), stridor, or daily oral corticosteroid treatment for >2 days before presentation.


salbutamol, 500 μg, 5 puffs given at 1 puff every 10 seconds from an MDI using a modified 500 ml plastic …

No Related Web Pages

Free Sample

This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of EBN.
View free sample issue >>

EBN Journal Chat

The EBN Journal Chat offers readers the opportunity to participate in discussion about research articles and commentaries from Evidence Based Nursing (EBN).

How to participate >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

Navigate This Article