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Review: antihistamines, decongestants, or both do not provide benefit in children with otitis media with effusion

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 Q Are antihistamines, decongestants, or both effective in treating children with otitis media with effusion (OME)?

METHODS

Embedded ImageData sources:

Cochrane Ear, Nose, and Throat Disorders Group Trials Register, Cochrane Central Register of Controlled Trials, Medline (1951–2006), EMBASE/Excerpta Medica (1974–2006), grey literature database, references of included trials and relevant reviews, manufacturers of decongestants and antihistamines, and authors in the field.

Embedded ImageStudy selection and assessment:

randomised controlled trials (RCTs) comparing oral or nasal decongestants or antihistamines with no medication or placebo in children ⩽18 years of age with OME. Trials in which the data of patients with acute otitis media, anatomical deformity, or other chronic immunocompromised states could not be separated from those of patients meeting criteria were excluded. 16 RCTs (n = 1737) met the selection criteria. The …

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