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Causation
Review: hypotonic solutions increase acute hyponatraemia in children receiving standard intravenous maintenance therapy

https://doi.org/10.1136/ebn.10.2.59

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    Choong K, Kho ME, Menon K, et al. Hypotonic versus isotonic saline in hospitalised children: a systematic review. Arch Dis Child 2006;91:828–35.OpenUrlAbstract/FREE Full Text

    Q In children receiving standard intravenous (IV) maintenance therapy in hospital, what is the relative safety of hypotonic and isotonic solutions?

    METHODS

    Embedded ImageData sources:

    Medline, EMBASE/Excerpta Medica (to 2006), Cochrane Library, Current Controlled Trials, conference proceedings and abstracts, reference lists, personal files, and experts in the field.

    Embedded ImageStudy selection and assessment:

    controlled trials, cohort studies, and case-control studies that evaluated adverse events (acute plasma sodium derangements and their attributed morbidity) associated with use of hypotonic (containing <0.9% sodium chloride) or isotonic (containing 0.9% sodium chloride or Ringers Lactate) IV maintenance solutions in children 1 month to 17 years …

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    Footnotes

    • For correspondence: Dr K Choong, Department of Paediatrics, McMaster University, Hamilton, Ontario, Canada. choongk{at}mcmaster.ca

    • Source of funding: not stated.