Review: hypotonic solutions increase acute hyponatraemia in children receiving standard intravenous maintenance therapy
Q In children receiving standard intravenous (IV) maintenance therapy in hospital, what is the relative safety of hypotonic and isotonic solutions?
Medline, EMBASE/Excerpta Medica (to 2006), Cochrane Library, Current Controlled Trials, conference proceedings and abstracts, reference lists, personal files, and experts in the field.
Study selection and assessment:
controlled trials, cohort studies, and case-control studies that evaluated adverse events (acute plasma sodium derangements and their attributed morbidity) associated with use of hypotonic (containing <0.9% sodium chloride) or isotonic (containing 0.9% sodium chloride or Ringers Lactate) IV maintenance solutions in children 1 month to 17 years of age who had been admitted to hospital for any medical or surgical condition. Patients with pre-existing hyponatraemia or comorbidities that …