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  • Postoperative ibuprofen increased bleeding complications in hospital and did not improve pain or physical function at 6–12 months after total hip replacement

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Postoperative ibuprofen increased bleeding complications in hospital and did not improve pain or physical function at 6–12 months after total hip replacement

https://doi.org/10.1136/ebn.10.2.57

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    Fransen M, Anderson C, Douglas J, et al for the HIPAID Collaborative Group. Safety and efficacy of routine postoperative ibuprofen for pain and disability related to ectopic bone formation after hip replacement surgery (HIPAID): randomised controlled trial. BMJ 2006;333:519.OpenUrlAbstract/FREE Full Text

    Q In patients having total hip replacement surgery, does 14 days of postoperative ibuprofen (as prophylaxis for ectopic bone formation) reduce pain and improve physical function 6–12 months after surgery? What are the effects on bleeding complications?

    METHODS

    Embedded ImageDesign:

    randomised, placebo controlled trial (HIPAID).

    Embedded ImageAllocation:

    concealed.

    Embedded ImageBlinding:

    blinded {patients, healthcare providers, data collectors, outcome assessors, data analysts, and monitoring committee}.*

    Embedded ImageFollow up period:

    6–12 months after surgery {median 7.8 mo}.*

    Embedded ImageSetting:

    20 hospitals in Australia and New Zealand.

    Embedded ImagePatients:

    902 patients (mean age 66 y, 54% men) who were identified within 24 …

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    Footnotes

    • ↵* Information provided by author.

    • For correspondence: Dr M Fransen, University of Sydney, New South Wales, Australia. mfransen{at}george.org.au

    • Sources of funding: National Health and Medical Research Council of Australia and Medical Benefits Fund of Australia.