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Postoperative ibuprofen increased bleeding complications in hospital and did not improve pain or physical function at 6–12 months after total hip replacement

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 Q In patients having total hip replacement surgery, does 14 days of postoperative ibuprofen (as prophylaxis for ectopic bone formation) reduce pain and improve physical function 6–12 months after surgery? What are the effects on bleeding complications?


Embedded ImageDesign:

randomised, placebo controlled trial (HIPAID).

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded {patients, healthcare providers, data collectors, outcome assessors, data analysts, and monitoring committee}.*

Embedded ImageFollow up period:

6–12 months after surgery {median 7.8 mo}.*

Embedded ImageSetting:

20 hospitals in Australia and New Zealand.

Embedded ImagePatients:

902 patients (mean age 66 y, 54% men) who were identified within 24 hours of elective total hip replacement surgery. Exclusion criteria were indication for or contraindication to non-steroidal anti-inflammatory drugs (NSAIDs), use of an NSAID (other than low dose aspirin) 48 hours before surgery, or …

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