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- arthroplasty (replacement, hip)
- anti-inflammatory agents (non-steroidal)
- ibuprofen
- pain (postoperative)
- ossification (heterotopic)
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Q In patients having total hip replacement surgery, does 14 days of postoperative ibuprofen (as prophylaxis for ectopic bone formation) reduce pain and improve physical function 6–12 months after surgery? What are the effects on bleeding complications?
METHODS
Design:
randomised, placebo controlled trial (HIPAID).
Allocation:
concealed.
Blinding:
blinded {patients, healthcare providers, data collectors, outcome assessors, data analysts, and monitoring committee}.*
Follow up period:
6–12 months after surgery {median 7.8 mo}.*
Setting:
20 hospitals in Australia and New Zealand.
Patients:
902 patients (mean age 66 y, 54% men) who were identified within 24 …
Footnotes
↵* Information provided by author.
For correspondence: Dr M Fransen, University of Sydney, New South Wales, Australia. mfransen{at}george.org.au
Sources of funding: National Health and Medical Research Council of Australia and Medical Benefits Fund of Australia.