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Evid Based Nurs 10:53 doi:10.1136/ebn.10.2.53
  • Treatment

Calcium reduced loss of bone mineral density but did not prevent fractures in healthy postmenopausal women


 
 Q Do calcium supplements reduce loss of bone mineral density (BMD) and prevent fractures in healthy postmenopausal women?

METHODS

GraphicDesign:

randomised, placebo controlled trial.

GraphicAllocation:

{concealed}.*

GraphicBlinding:

blinded {patients and clinicians}.*

GraphicFollow up period:

5 years (mean 4.5 y).

GraphicSetting:

{university medical centre}* in Auckland, New Zealand.

GraphicParticipants:

1471 healthy postmenopausal women >55 years of age (mean age 74 y) who were not taking calcium or drugs for osteoporosis; had serum creatinine concentrations <2.3 mg/dl (0.2 mmol/l) and 25-hydroxyvitamin D >10 µg/l (25 nmol/l); and had lumbar spine BMD in the normal range for age.

GraphicIntervention:

elemental calcium (as citrate), 1 g daily (n = 732), or placebo, taken in 2 divided doses {2 tablets before breakfast and 3 tablets in the evening} …

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