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Q In patients with diabetes, what is the relative efficacy, safety, and acceptability of inhaled insulin compared with subcutaneous (SC) insulin and oral hypoglycaemic agents?
Medline (June 2006), Cochrane Controlled Clinical Trials Register (Issue 2, 2006), reference lists, and the US Food and Drug Administration web site.
Study selection and assessment:
English language randomised controlled trials (RCTs) that compared inhaled insulin with SC insulin or oral hypoglycaemic agents in non-pregnant adults with type 1 or type 2 diabetes and had a duration ⩾12 weeks. 16 RCTs (n = 4023, mean age range 29–60 y, 58% men) met the selection criteria. Methodological quality was assessed based on randomisation method, intention to treat analysis, dropout rate, and primary outcome (efficacy or safety).
change in haemoglobin A1c (HbA1c …
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