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Q Does reduction in exposure to house dust mite (HDM) allergens and modification of dietary fatty acids in the first 5 years of life reduce the risk of asthma at 5 years of age?
METHODS
Design:
randomised, 2×2 factorial, placebo controlled trial.
Allocation:
{concealed}.*
Blinding:
blinded {participants [diet intervention only] and outcome assessors}.*
Follow up period:
5 years.
Setting:
{recruitment in antenatal clinics of 6 hospitals in Sydney, Australia}.* Interventions were done in children’s homes.
Participants:
616 pregnant women (mean age 29 y), whose unborn singleton child was at increased risk of developing asthma because of asthma in a first degree relative. Infants born at <36 weeks’ gestation, with birth weight <2.5 kg or significant congenital malformation or …
Footnotes
For correspondence: Dr G B Marks, Woolcock Institute of Medical Research, Camperdown, New South Wales, Australia. g.marks{at}unsw.edu.au
Sources of funding: National Health and Medical Research Council of Australia and New South Wales Department of Health.