Environmental and dietary interventions in the first 5 years of life did not reduce the risk of asthma and allergic disease
Q Does reduction in exposure to house dust mite (HDM) allergens and modification of dietary fatty acids in the first 5 years of life reduce the risk of asthma at 5 years of age?
METHODS
Design:
randomised, 2×2 factorial, placebo controlled trial.
Allocation:
{concealed}.*
Blinding:
blinded {participants [diet intervention only] and outcome assessors}.*
Follow up period:
5 years.
Setting:
{recruitment in antenatal clinics of 6 hospitals in Sydney, Australia}.* Interventions were done in children’s homes.
Participants:
616 pregnant women (mean age 29 y), whose unborn singleton child was at increased risk of developing asthma because of asthma in a first degree relative. Infants born at <36 weeks’ gestation, with birth weight <2.5 kg or significant congenital malformation or neonatal disease were withdrawn.
Interventions:
active HDM intervention (allergen impermeable barrier on the child’s bed, regular washing of bedding, and use of benzyl benzoate in the …
