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  • Environmental and dietary interventions in the first 5 years of life did not reduce the risk of asthma and allergic disease

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Environmental and dietary interventions in the first 5 years of life did not reduce the risk of asthma and allergic disease

https://doi.org/10.1136/ebn.10.2.44

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    Marks GB, Mihrshahi S, Kemp AS, et al. Prevention of asthma during the first 5 years of life: a randomized controlled trial. J Allergy Clin Immunol 2006;118:53–61.OpenUrlCrossRefPubMedWeb of Science

    Q Does reduction in exposure to house dust mite (HDM) allergens and modification of dietary fatty acids in the first 5 years of life reduce the risk of asthma at 5 years of age?

    METHODS

    Embedded ImageDesign:

    randomised, 2×2 factorial, placebo controlled trial.

    Embedded ImageAllocation:

    {concealed}.*

    Embedded ImageBlinding:

    blinded {participants [diet intervention only] and outcome assessors}.*

    Embedded ImageFollow up period:

    5 years.

    Embedded ImageSetting:

    {recruitment in antenatal clinics of 6 hospitals in Sydney, Australia}.* Interventions were done in children’s homes.

    Embedded ImageParticipants:

    616 pregnant women (mean age 29 y), whose unborn singleton child was at increased risk of developing asthma because of asthma in a first degree relative. Infants born at <36 weeks’ gestation, with birth weight <2.5 kg or significant congenital malformation or …

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    Footnotes

    • ↵* Mihrshahi S, Peat JK, Webb K, et al. Control Clin Trials 2001;22:333–54.OpenUrlCrossRefPubMedWeb of Science

    • For correspondence: Dr G B Marks, Woolcock Institute of Medical Research, Camperdown, New South Wales, Australia. g.marks{at}unsw.edu.au

    • Sources of funding: National Health and Medical Research Council of Australia and New South Wales Department of Health.