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Evid Based Nurs 10:24 doi:10.1136/ebn.10.1.24
  • Causation

Review: good adherence to drug therapy is associated with reduced mortality


 
 Q What is the relation between adherence to drug therapy and mortality?

METHODS

GraphicData sources:

AMED, CINAHL, Embase/Excerpta Medica, ERIC, HealthSTAR, Medline, PsycINFO, and Web of Science (all from inception to June 2005); and references from textbooks and review articles.

GraphicStudy selection and assessment:

randomised controlled trials (RCTs) or observational studies in any language that evaluated the association between adherence to drug therapy and mortality, explained methods used to measure adherence, provided clear definitions of good adherence, and stratified patients into good and poor adherence groups. Studies that did not provide data on the number of deaths in each adherence group were excluded. 8 RCTs (n = 37 701) and 13 …

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