Evid Based Nurs 10:19 doi:10.1136/ebn.10.1.19
  • Treatment

Oral decontamination with chlorhexidine reduced ventilator associated pneumonia in patients needing mechanical ventilation for ⩾48 hours

Chlorhexidine (CHX) or CHX plus colistin (COL) v placebo in mechanically ventilated patients*

Outcome† CHX CHX + COL Placebo RRR (95% CI) NNT (CI)
*Abbreviations defined in glossary; RRR, NNT, and CI calculated from control event rates and hazard ratios in article.
†Follow up to diagnosis of ventilator associated pneumonia, death, or extubation.
Ventilator associated pneumonia 10% 18% 63% (19 to 83) 10 (7 to 30)
13% 18% 52% (7 to 76) 11 (8 to 83)

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