Evid Based Nurs 10:19 doi:10.1136/ebn.10.1.19
  • Treatment

Oral decontamination with chlorhexidine reduced ventilator associated pneumonia in patients needing mechanical ventilation for ⩾48 hours

 Q In patients requiring mechanical ventilation for ⩾48 hours, is oral decontamination with chlorhexidine (CHX) or CHX plus colistin (COL) effective for reducing ventilator associated pneumonia (VAP)?



randomised placebo controlled trial.




blinded (clinicians, patients, {outcome assessors, data collectors, data analysts, monitoring committee, manuscript writers, and pharmacists of participating centres}*).

GraphicFollow up period:

up to diagnosis of VAP, death, or extubation.


2 mixed and 2 surgical intensive care units (ICUs) in 2 university hospitals and mixed ICUs in 3 general hospitals in the Netherlands.


385 patients >18 years of age (mean age 62 y, 60% men) requiring mechanical ventilation for ⩾48 hours. Exclusion criteria were preadmission immunocompromised status (defined as leucopaenia <3 × 109/l, cumulative dose of corticosteroids >750 mg/y, or human …

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